Cardiovascular disease affects approximately 60% of the adult population over the age of 65
and represents the number one cause of death in the United States. Coronary …

Hyperglycemic episodes, which complicate even well-controlled cases of diabetes, lead to
increased polyol pathway flux, activation of protein kinase C and accelerated non-enzymatic …

Endothelial dysfunction may precede development of type 2 diabetes. We tested the
hypothesis that elevated levels of hemostatic markers of endothelial dysfunction …

Objective: Obesity is linked with large vessel atherosclerosis and diabetes. Its association
with microvascular changes is less clear. We investigated the associations among retinal …

Objective—The mechanisms responsible for the increased cardiovascular disease risk that
accompanies type 2 diabetes (T2D) remain poorly understood. It is commonly held that …

Objectives: This study sought to determine whether metformin improves vascular function or
myocardial ischemia in nondiabetic subjects. Background: Metformin prevents diabetes and …

AIMS: Vascular endothelial cells play a major role in maintaining cardiovascular
homeostasis in health. Diabetes mellitus (DM) substantially impairs the vasodilating …

Objective—Using the Monitoring of Trends and Determinants in Cardiovascular Disease
(MONICA)/Cooperative Research in the Region of Augsburg (KORA) database, we …

Vessels in the skin are arranged into superficial and deep horizontal plexuses and they are
involved in thermoregulation, oxygen and nutritional support. The skin has a large number of …

Peripheral neuropathy is a common problem encountered by neurologists and primary care
physicians. While there are many causes for peripheral neuropathy, none can be identified …