Microsatellite instability in colorectal cancer
K Söreide, EAM Janssen, H Söiland… - Journal of British …, 2006 - academic.oup.com
Background Microsatellite instability (MSI) causes hereditary non-polyposis colorectal
cancer (HNPCC), and occurs in about 15 per cent of sporadic colorectal cancers. Although …
cancer (HNPCC), and occurs in about 15 per cent of sporadic colorectal cancers. Although …
CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer
DJ Weisenberger, KD Siegmund, M Campan… - Nature …, 2006 - nature.com
Aberrant DNA methylation of CpG islands has been widely observed in human colorectal
tumors and is associated with gene silencing when it occurs in promoter areas. A subset of …
tumors and is associated with gene silencing when it occurs in promoter areas. A subset of …
Comparison of microsatellite instability, CpG island methylation phenotype, BRAF and KRAS status in serrated polyps and traditional adenomas indicates separate …
MJ O'Brien, S Yang, C Mack, H Xu… - The American journal …, 2006 - journals.lww.com
The aim of this study was to compare BRAF and KRAS, CpG island methylator phenotype
(CIMP), and microsatellite instability (MSI) status in each of the histologic categories …
(CIMP), and microsatellite instability (MSI) status in each of the histologic categories …
Chromosomal instability in microsatellite-unstable and stable colon cancer
K Trautmann, JP Terdiman, AJ French… - Clinical cancer …, 2006 - AACR
Purpose: The genomic instability in colon cancer can be divided into at least two major
types, microsatellite instability (MSI) or chromosomal instability (CIN). Although initially felt to …
types, microsatellite instability (MSI) or chromosomal instability (CIN). Although initially felt to …
Association of JC virus T-antigen expression with the methylator phenotype in sporadic colorectal cancers
A Goel, MS Li, T Nagasaka, SK Shin, F Fuerst… - Gastroenterology, 2006 - Elsevier
Background & Aims: JC virus (JCV) is a polyomavirus that ubiquitously infects humans and
has been implicated in various human cancers. JCV encodes a “transforming” gene, T …
has been implicated in various human cancers. JCV encodes a “transforming” gene, T …
Epithelial and stromal genetic instability contributes to genesis of colorectal adenomas
K Ishiguro, T Yoshida, H Yagishita, Y Numata… - Gut, 2006 - gut.bmj.com
Background: Previously, we indicated that stromal genetic instability might contribute to
tumorigenesis of both sporadic and ulcerative colitis associated colorectal …
tumorigenesis of both sporadic and ulcerative colitis associated colorectal …
Genome-wide differences between microsatellite stable and unstable colorectal tumors
Genomic copy number changes are frequently found in cancers and they have been
demonstrated to contribute to carcinogenesis; and it is widely accepted that tumors with …
demonstrated to contribute to carcinogenesis; and it is widely accepted that tumors with …
Histologic features distinguish microsatellite-high from microsatellite-low and microsatellite-stable colorectal carcinomas, but do not differentiate germline mutations …
The detection of microsatellite-unstable (microsatellite instability [MSI]) colorectal
carcinomas (CRCs) has prognostic value and can help screen for Lynch syndrome. We …
carcinomas (CRCs) has prognostic value and can help screen for Lynch syndrome. We …
Clinicopathological characteristics, microsatellite instability, and expression of mucin core proteins and p53 in colorectal mucinous adenocarcinomas in relation to …
It has been suggested that right-sided and left-sided colorectal cancer may arise by different
mechanisms. However, there have been few studies of mucinous adenocarcinoma (MA) in …
mechanisms. However, there have been few studies of mucinous adenocarcinoma (MA) in …
RAB32 hypermethylation and microsatellite instability in gastric and endometrial adenocarcinomas
D Shibata, Y Mori, K Cai, L Zhang, J Yin… - … journal of cancer, 2006 - Wiley Online Library
The recently described gene, RAB32, is a ras proto‐oncogene family member that encodes
an A‐kinase‐anchoring protein. RAB32 has been found to be frequently hypermethylated in …
an A‐kinase‐anchoring protein. RAB32 has been found to be frequently hypermethylated in …