It is increasingly apparent that cancer development not only depends on genetic alterations
but on an abnormal cellular memory, or epigenetic changes, which convey heritable gene …

The term epigenetics defines a heritable alteration in gene expression without an
accompanying change in primary DNA sequence. Two major mechanisms that foster …

We studied the relationships between genetic and epigenetic alterations in gastrointestinal
cancer by integrating DNA copy number changes determined by arbitrarily primed PCR (AP …

A major obstacle toward understanding how patterns of abnormal mammalian cytosine DNA
methylation are established is the difficulty in quantitating the de novo methylation activities …

The epigenome, which comprises chromatin, associated proteins, and the pattern of
covalent modification of DNA by methylation, sets up and maintains gene expression …

There is increasing evidence to suggest that reduced folate status may be a causative factor
in carcinogenesis, particularly colorectal carcinogenesis. Folate is essential for the synthesis …

Whilst genetic alterations in oral cancer have long been documented, the appreciation of
epigenetic changes is more recent. Epigenetic changes alter expression of tumour …

Aberrant gene silencing accompanied by DNA methylation is associated with neoplastic
progression in many tumors that also show global loss of DNA methylation. Using …

This study was performed to determine whether promotor hypomethylation of CAGE is
involved in cervical carcinogenesis. The surgical specimens of 40 cervical squamous cell …

Gene silencing is a general term describing epigenetic processes of gene regulation. The
term gene silencing is generally used to describe the'switching off'of a gene by a mechanism …