Nuclear Localization of PTEN Is Regulated by Ca2+ through a Tyrosil Phosphorylation–Independent Conformational Modification in Major Vault Protein

T Minaguchi, KA Waite, C Eng - Cancer research, 2006 - AACR
We have recently shown in MCF-7 cells that nuclear phosphatase and tensin homologue
deleted on chromosome 10 (PTEN) down-regulates phosphorylation of p44/42 and cyclin …

The vault exterior shell is a dynamic structure that allows incorporation of vault-associated proteins into its interior

MJ Poderycki, VA Kickhoefer, CS Kaddis… - Biochemistry, 2006 - ACS Publications
Vaults are 13 million Da ribonucleoprotein particles with a highly conserved structure.
Expression and assembly by multimerization of an estimated 96 copies of a single protein …