The apoB/apoA‐I ratio: a strong, new risk factor for cardiovascular disease and a target for lipid‐lowering therapy–a review of the evidence

G Walldius, I Jungner - Journal of internal medicine, 2006 - Wiley Online Library
During the last several years interest has focused on the importance of the lipid‐transporting
apolipoproteins–apoB transports all potentially atherogenic very low‐density lipoprotein …

Detection and treatment of vulnerable plaques and vulnerable patients: novel approaches to prevention of coronary events

S Waxman, F Ishibashi, JE Muller - Circulation, 2006 - Am Heart Assoc
However, there is also evidence that the lesions causing clinical events are focal.
Interventional cardiologists generally find that a single location is responsible for an acute …

Reported outcomes in major cardiovascular clinical trials funded by for-profit and not-for-profit organizations: 2000-2005

PM Ridker, J Torres - Jama, 2006 - jamanetwork.com
ContextIn surveys based on data available prior to 2000, clinical trials funded by for-profit
organizations appeared more likely to report positive findings than those funded by not-for …

Canadian Cardiovascular Society position statement–recommendations for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease

R McPherson, J Frohlich, G Fodor, J Genest - Canadian Journal of …, 2006 - Elsevier
Since the last publication of the recommendations for the management and treatment of
dyslipidemia, new clinical trial data have emerged that support a more vigorous approach to …

High-dose β-blockers and tight heart rate control reduce myocardial ischemia and troponin T release in vascular surgery patients

HHH Feringa, JJ Bax, E Boersma, MD Kertai, SH Meij… - Circulation, 2006 - Am Heart Assoc
Background—Adverse perioperative cardiac events occur frequently despite the use of beta
(β)-blockers. We examined whether higher doses of β-blockers and tight heart rate control …

Nutrition and stroke prevention

M Fisher, K Lees, JD Spence - Stroke, 2006 - Am Heart Assoc
Nutrition is much more important in prevention of stroke than is appreciated by most
physicians. The powerful effects of statin drugs in lowering the levels of fasting cholesterol …

[HTML][HTML] Comparison of the efficacy and safety of rosuvastatin 10 mg and atorvastatin 20 mg in high-risk patients with hypercholesterolemia–Prospective study to …

MB Clearfield, J Amerena, JP Bassand, HRH García… - Trials, 2006 - Springer
Background Many patients at high risk of cardiovascular disease do not achieve
recommended low-density lipoprotein cholesterol (LDL-C) goals. This study compared the …

Carotid intima-media thickness as a surrogate marker for cardiovascular disease in intervention studies

ML Bots - Current medical research and opinion, 2006 - Taylor & Francis
Background: Cardiovascular trials using clinical endpoints to assess efficacy typically
require followup of large numbers of participants for 3–5 years. This disadvantage has …

Rethinking primary prevention of atherosclerosis-related diseases

C Napoli, LO Lerman, F De Nigris, M Gossl… - Circulation, 2006 - Am Heart Assoc
only for expansion of our understanding of the pathogenesis of the disease but also to form
the basis for clinical considerations (reviewed elsewhere24). The mechanism by which …

[HTML][HTML] Thematic review series: patient-oriented research. Imaging atherosclerosis: state of the art

JR Crouse - Journal of Lipid Research, 2006 - ASBMB
The ability to image obstructive arterial disease brought about a revolution in clinical
cardiovascular care; the development of newer technologies that image arterial wall …