In healthy cells, cytochrome c (Cyt c) is located in the mitochondrial intermembrane/
intercristae spaces, where it functions as an electron shuttle in the respiratory chain and …

Mitochondrial outer membrane permeabilization (MOMP) is considered the 'point of no
return'as this event is responsible for engaging the apoptotic cascade in numerous cell …

We show that the antiapoptotic proteins BCL-2, BCL-XL, MCL-1, BFL-1, and BCL-w each
bear a unique pattern of interaction with a panel of peptides derived from BH3 domains of …

Neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease trigger
neuronal cell death through endogenous suicide pathways. Surprisingly, although the cell …

Cell survival has been closely linked to both trophic growth factor signaling and cellular
metabolism. Such couplings have obvious physiologic and pathophysiologic implications …

Bcl-2-family proteins are central regulators of cell life and death. At least three major classes
of Bcl-2-family proteins have been delineated, including proapoptotic proteins that contain …

The complexity of the p53 protein, coupled with the vast cellular responses to p53, is simply
astonishing. As new isoforms, functional domains and protein–protein interactions are …

BAX is a multidomain proapoptotic BCL-2 family protein that resides in the cytosol until
activated by an incompletely understood trigger mechanism, which facilitates BAX …

Commitment of cells to apoptosis is governed largely by protein-protein interactions
between members of the Bcl-2 protein family. Its three sub-families have distinct roles: the …

Loss of Ca2+ homeostasis, often in the form of cytoplasmic increases, leads to cell injury.
Depending upon cell type and the intensity of Ca2+ toxicity, the ensuing pathology can be …