Cell-based antitumor immunity is driven by CD8+ cytotoxic T cells bearing TCR that
recognize specific tumor-associated peptides bound to class I MHC molecules. Of several …

Antigen-specific tumor immunotherapy remains an attractive strategy for the treatment of
malignancies. In this review we will discuss why, despite the identification of large numbers …

Cell-based cancer vaccines are a highly attractive alternative to standard cancer therapies.
They theoretically have the capability of inciting a multitargeted therapeutic response that …

Fusion of peptides to viral carriers has proven an effective method for improving cellular
immunity. In this study we explore the ability of a plant virus, Tobacco mosaic virus (TMV), to …

The CD8 coreceptor on T cells has two functions. Namely, CD8 acts to stabilize the binding
of the T-cell receptor (TCR) to the peptide-MHC complex while localizing p56lck (lck) to the …

We identified a series of immunodominant and subdominant epitopes from α fetoprotein
(AFP), restricted by HLA-A* 0201, which are recognized by the human T cell repertoire. The …

Chemical conjugation of CTL peptides to tobacco mosaic virus (TMV) has shown promise as
a molecular adjuvant scaffold for augmentation of cellular immune responses to peptide …

The adoptive transfer of in vitro-induced and expanded tumor-specific cytotoxic T
lymphocytes (CTL) presents a promising immunotherapeutic approach for the treatment of …

The induction of a potent and specific T cell response is a major challenge in the
development of efficacious cancer vaccine strategies. We applied a novel liposomal …

Protein transduction domains (PTDs) have been used increasingly to deliver reagents to a
variety of cell types in vitro and in vivo. We have previously shown that HIV TAT-PTD …