Drugs, their targets and the nature and number of drug targets | Nature Reviews Drug Discovery
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The concept of platform synthesis has been successfully demonstrated as a useful strategy
for making multisubstituted olefins in a programmable and diversity-oriented format. As well …

Emergence of library‐based approaches have changed the way of developing new
functional molecules in materials science and pharmaceutical science. Therefore, reliable …

Antiestrogens used for breast cancer (BC) treatment differ among each other for the ability to
affect estrogen receptor (ER) activity and thereby inhibit hormone‐responsive cell functions …

Ynolates were found to react with α‐alkoxy‐, α‐siloxy‐, and α‐aryloxyketones at room
temperature to afford tetrasubstituted olefins with high Z selectivity. Since the geometrical …

Background: In breast cancer, the expression of CD24 represents a poorly recognised
unfavourable prognostic factor. CD24 has been described to be potentially down-regulated …

The utility of the 2-pyridylsilyl group as a multifunctional group in organic synthesis is
described. The use of the 2-pyridylsilyl group as a removable directing group is a powerful …

Abstract Diels–Alder and Friedel–Crafts reactions of [3] cumulene 1 were investigated.
Although the Diels–Alder reaction with cyclopentadiene selectively occurred on the C2, 3 …

Although many indirect methods have been chosen to study the system of estrogen receptor
ligand binding, an ideal method is fluorescence correlation spectroscopy (FCS). FCS is …

The Heck reaction of an unsymmetrically substituted [3] cumulene has been investigated.
Although a carbonyl conjugated alkene is present, the arylpalladium species selectively …