A large number of neurodegenerative diseases in humans result from protein misfolding and
aggregation. Protein misfolding is believed to be the primary cause of Alzheimer's disease …

During the past 5 years, gene expression studies in cell culture, animal models and in the
brains of patients have shown that the perturbation of transcription frequently results in …

Expansion of a polyglutamine tract in ataxin-3 (AT3) results in spinocerebellar ataxia type
3/Machado–Joseph disease, one of the nine polyglutamine neurodegenerative diseases …

The aggregation of ataxin-3 is associated with spinocerebellar ataxia type 3, which is
characterized by the formation of intraneuronal aggregates. However, the mechanism of …

Abstract Spinocerebellar ataxia type 3 (SCA3), like other polyglutamine (polyQ) diseases, is
characterized by the formation of intraneuronal inclusions, but the mechanism underlying …

Spinocerebellar ataxia type 3 (SCA3) is an autosomal dominant neurodegenerative disease
caused by polyglutamine-expanded ataxin-3. In the present study, we expressed disease …

In the last years progress has been made regarding the involvement of the thalamus during
the course of the currently known polyglutamine diseases. Although recent studies have …

Objective Spinal and bulbar muscular atrophy (SBMA) is a hereditary motor neuron disease
caused by the expansion of a polyglutamine tract in the androgen receptor (AR). The …

The expanded polyglutamine (polyQ) tracts observed in autosomal dominant
neurodegenerative disorders have the tendency to form intracellular aggregates, thus …

The formation of polyglutamine aggregates occupies a central role in the pathophysiology of
neurodegenerative diseases caused by expanded trinucleotide repeats encoding the amino …