Fluorescence microscopy is a powerful method to study protein function in its natural habitat,
the living cell. With the availability of the green fluorescent protein and its spectral variants …

The application of confocal laser scanning microscopy (CLSM) to the physicochemical
characterisation of pharmaceutical systems is not as widespread as its application within the …

Advances in biotechnology have led to an accelerated discovery of macromolecular
therapeutics such as peptides, proteins and polynucleotides. These macromolecules can be …

Tissue engineering is a multidisciplinary field that combines engineering, physical sciences,
biology, and medicine to restore or replace tissues and organs functions. In this review …

Cell-permeable small molecules can be used to modulate protein function selectively,
rapidly, reversibly, and conditionally with temporal and quantitative control in biological …

As they are often designed for lysosomotropic, endosomotropic and/or transcellular delivery,
an understanding of intracellular trafficking pathways is essential to enable optimised design …

Non-invasive methods for studying biological processes in living cells have become very
important, also in the field of GPCR biochemistry. Great advancements in the application of …

An exponentially growing number of nanotechnology-based products are providing new
platforms for research in different scientific disciplines (eg, life sciences and medicine) …

There is increasing interest in the usefulness of block copolymer micelles as drug delivery
vehicles. However, their subcellular distribution has not been explored extensively, mostly …

Antisense strategy represents a promising molecular tool for efficient and selective
chemotherapeutic action. It belongs among oligonucleotide strategies that employ specific …