Human saliva proteome analysis and disease biomarker discovery

S Hu, JA Loo, DT Wong - Expert review of proteomics, 2007 - Taylor & Francis
Human saliva is an attractive body fluid for disease diagnosis and prognosis because saliva
testing is simple, safe, low-cost and noninvasive. Comprehensive analysis and identification …

Genomic targets in saliva

BG Zimmermann, NJ Park… - Annals of the New York …, 2007 - Wiley Online Library
Saliva, the most accessible and noninvasive biofluid of our body, harbors a wide spectrum of
biological analytes informative for clinical diagnostic applications. While proteomic …

Soluble CD44 is a potential marker for the early detection of head and neck cancer

EJ Franzmann, EP Reategui, F Pedroso… - … Biomarkers & Prevention, 2007 - AACR
Introduction: Head and neck squamous cell carcinoma (HNSCC) is a devastating and
deadly disease, largely because it is diagnosed in late stage. Cure rates, currently at 50 …

Comparison of salivary cytokine levels in oral cancer patients and healthy subjects

A Katakura, I Kamiyama, N Takano… - The Bulletin of Tokyo …, 2007 - jstage.jst.go.jp
In order to find informative salivary biomarkers specific to oral cancer we examined
expression of 4 kinds of cytokine in saliva. Levels of interleukins (IL-1,-6,-8) and osteopontin …

Characterization of salivary RNA by cDNA library analysis

NJ Park, X Zhou, T Yu, BMN Brinkman… - Archives of oral …, 2007 - Elsevier
Oral fluid (saliva) meets the demands for a noninvasive and accessible diagnostic medium.
Recent reports by our group and others described the presence and use of human RNA in …

Aberrant cytokine expression in serum of patients with adenoid cystic carcinoma and squamous cell carcinoma of the head and neck

TK Hoffmann, E Sonkoly, B Homey… - Head & Neck …, 2007 - Wiley Online Library
Background. Squamous cell carcinoma (SCC) and adenoid cystic carcinoma (ACC)
represent 2 clinically important subtypes of head and neck cancer. Our objective was to …

Implications of salivary proteomics in drug discovery and development: a focus on cancer drug discovery

S Hu, Y Yen, D Ann, DT Wong - Drug discovery today, 2007 - Elsevier
Human saliva proteomics has proven to be a novel approach in the search for protein
biomarkers for non-invasive detection of human cancers. This approach may also have …

Angiogenesis meets immunology: cytokine gene therapy of cancer

S Minuzzo, L Moserle, S Indraccolo… - Molecular Aspects of …, 2007 - Elsevier
Delivery of cytokine genes at the tumor site in pre-clinical models has been shown to recruit
host inflammatory cells followed by inhibition of tumor growth. This local effect is often …

Diagnostic potential of genomic and proteomic signatures in oral cancer

R Ralhan - International Journal of Human Genetics, 2007 - Taylor & Francis
Oral cancer is a public health problem with increasing incidence and mortality rates
worldwide. Despite rapid advances in treatment, 5year survival rates have not improved …

[PDF][PDF] SALIVARY DIAGNOSTICS: ENHANCING DISEASE DETECTION AND MAKING MEDICINE BETTER

DT Wong - Citeseer
Global Congress on Dental Education September 2007 Keynote Address Dr. David Wong 1-17
Dr. David TW Wong Biosketch David Wong Page 1 Global Congress on Dental Education …