The acquisition of invasive behaviour is the key transition in the progression of benign
melanocyte hyperplasia to life threatening melanoma. Understanding this transition and the …

Bone sialoprotein (BSP) is an acidic, noncollagenous glycoprotein abundantly expressed in
mineralized tissues. Although BSP is frequently used as a marker of osteoblast …

The management of pain and morbidity due to the spreading and growth of cancer within
bone remains to be a paramount problem in clinical care. Cancer cells actively transform …

Malignant ascites is a major source of morbidity and mortality in ovarian cancer patients. It
functions as a permissive reactive tumor-host microenvironment and provides sustenance …

Divalent cations like Mn2+ are known to strongly influence the integrin affinity to ligands and–
in consequence–cell adhesion to extracellular matrix proteins. Therefore, divalent cation …

The matricellular glycoprotein SPARC (secreted protein acidic and rich in cysteine) has
been accorded major roles in regulation of cell adhesion and proliferation, as well as …

Ziel der Arbeit ist es, ein Modell zur Testung der Bioverträglichkeit von Materialoberflächen
zu evaluieren. Für gewöhnlich binden Zellen mittels von Integrinen nicht an die eigentliche …

The adaptation of the skeleton to changes in mechanical loading depends on the ability of
bone cells first to detect then to convert diverse mechanical forces into chemical signals that …

Various members of the insulin-like growth factor (IGF) family of growth factors are highly
expressed in bone tissue and are vitally important for the normal development and function …

The effect of Mn on the protein adsorption of calcium phosphate coatings is investigated in
this work. Mn containing β-tricalcium phosphate (Mn-TCP) is first prepared through a …