Histone deacetylase inhibitors: molecular mechanisms of action
WS Xu, RB Parmigiani, PA Marks - Oncogene, 2007 - nature.com
This review focuses on the mechanisms of action of histone deacetylase (HDAC) inhibitors
(HDACi), a group of recently discovered 'targeted'anticancer agents. There are 18 HDACs …
(HDACi), a group of recently discovered 'targeted'anticancer agents. There are 18 HDACs …
Mechanisms of resistance to histone deacetylase inhibitors and their therapeutic implications
VR Fantin, VM Richon - Clinical cancer research, 2007 - AACR
Histone deacetylase inhibitors (HDI) are a promising new approach to the treatment of
cancer. HDIs have been shown to induce differentiation, cell cycle arrest, and apoptosis in a …
cancer. HDIs have been shown to induce differentiation, cell cycle arrest, and apoptosis in a …
Apoptosis induced by histone deacetylase inhibitors in leukemic cells is mediated by Bim and Noxa
S Inoue, J Riley, TW Gant, MJS Dyer, GM Cohen - Leukemia, 2007 - nature.com
Several histone deacetylase inhibitors (HDACi), which have recently entered early clinical
trials, exert their anticancer activity in part through the induction of apoptosis although the …
trials, exert their anticancer activity in part through the induction of apoptosis although the …
Combined effects of retinoic acid and histone deacetylase inhibitors on human neuroblastoma SH-SY5Y cells
M De los Santos, A Zambrano, A Aranda - Molecular cancer therapeutics, 2007 - AACR
All-trans retinoic acid (RA) causes differentiation of neuroblastoma cells, and retinoids have
been used in clinical trials in children with advanced neuroblastoma. Combination of RA …
been used in clinical trials in children with advanced neuroblastoma. Combination of RA …
Histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis through both mitochondrial and Fas (Cd95) signaling in head and neck squamous …
AM Gillenwater, M Zhong, R Lotan - Molecular cancer therapeutics, 2007 - AACR
Alterations in histone acetylation status have been implicated in carcinogenesis. Histone
deacetylase inhibitors, such as suberoylanilide hydroxamic acid (SAHA), can potentially …
deacetylase inhibitors, such as suberoylanilide hydroxamic acid (SAHA), can potentially …
Histone deacetylase inhibitors in cancer therapy: latest developments, trends and medicinal chemistry perspective
KV Balakin, YA Ivanenkov, AS Kiselyov… - Anti-Cancer Agents …, 2007 - ingentaconnect.com
Regulation of gene expression is mediated by several mechanisms such as DNA
methylation, ATP-dependent chromatin remodeling, and post-translational modifications of …
methylation, ATP-dependent chromatin remodeling, and post-translational modifications of …
Depsipeptide a histone deacetlyase inhibitor down regulates levels of matrix metalloproteinases 2 and 9 mRNA and protein expressions in lung cancer cells (A549)
R Vinodhkumar, YS Song, V Ravikumar… - Chemico-biological …, 2007 - Elsevier
BACKGROUND: A novel histone deacetylase inhibitor, depsipeptide FR901228 (FK228), is
a promising anticancer and antiproliferative agent and has been proposed to regulate gene …
a promising anticancer and antiproliferative agent and has been proposed to regulate gene …
Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors
CJ Watkins, MR Romero-Martin, KG Moore… - US Patent …, 2007 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
27255912&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
27255912&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
De novo Identification of MIZ-1 (ZBTB17) Encoding a MYC-Interacting Zinc-Finger Protein as a New Favorable Neuroblastoma Gene
N Ikegaki, T Gotoh, B Kung, JS Riceberg, DY Kim… - Clinical cancer …, 2007 - AACR
Purpose: Neuroblastoma is a childhood cancer that exhibits either a favorable or an
unfavorable phenotype. Favorable neuroblastoma genes (EPHB6, EFNB2, EFNB3, NTRK1 …
unfavorable phenotype. Favorable neuroblastoma genes (EPHB6, EFNB2, EFNB3, NTRK1 …
Inhibitors of histone deacetylase
D Delorme, R Lavoie, C Thibault… - US Patent App. 10 …, 2007 - Google Patents
JP 11-302173 11, 1999 WO WO 90/O1929 3, 1990 WO WO 93.12075 6, 1993 WO
WO93/12075 A1 6, 1993 WO WO95/13264 5, 1995 WO WO-A-95.06554 9, 1995 WO WO …
WO93/12075 A1 6, 1993 WO WO95/13264 5, 1995 WO WO-A-95.06554 9, 1995 WO WO …