Neurodegenerative disorders, such as Alzheimer's disease, are often characterised by the
degeneration of the cholinergic system. Thus, the aim of many treatment regimens is to …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the central
nervous system (CNS) which is the most common cause of dementia in the elderly. It is …

The first edition of this book, Chemical Warfare Agents: Toxicity at Low Levels, was
published just prior to the terrorist attacks of September 11th, 2001. Reflecting a greater …

Central cholinergic systems are involved in a plethora of brain functions and are severely
and selectively damaged in neurodegenerative diseases such as Alzheimer's disease and …

Objective We investigated the association between the serum butyrylcholinesterase (BChE)
activity and parameters of adiposity, insulin resistance and the serum lipid profile, including …

3-n-Butylphthalide (NBP) may be beneficial for the treatment of ischemic stroke with multiple
actions on different pathophysiological processes. In the present study, we investigated the …

Butyrylcholinesterase (EC 3.1. 1.8 BChE) is present in all human and mouse tissues, and is
more abundant than acetylcholinesterase (EC 3.1. 1.7 AChE) in all tissues except brain …

Phenserine, a derivative of physostigmine, was first described as an inhibitor of
acetylcholinesterase (AChE) and was shown to improve cognition in various experimental …

Two cationic phenoxazine dyes, meldola blue (MB) and nile blue (NB), and the structurally
related phenothiazine, methylene blue (MethB), were found to act as complex inhibitors of …

Acetylcholinesterase reactivators are crucial antidotes for the treatment of organophosphate
intoxication. Fifteen new monooxime reactivators of acetylcholinesterase with a (E)-but-2 …