Abstract von Hippel-Lindau disease, which is characterized by an increased risk of
hemangioblastomas, clear cell renal carcinomas, and pheochromocytomas, is caused by …

Malignant phaeochromocytomas are rare tumours accounting for~ 10% of all
phaeochromocytomas; the prevalence of malignancy among paragangliomas is higher …

Succinate dehydrogenase (SDH) and fumarate hydratase (FH) are components of the
tricarboxylic acid (TCA) cycle and tumor suppressors. Loss of SDH or FH induces …

It has been known for quite some time that cancer cells undergo far-reaching modifications
in their metabolism, yet a full understanding of these changes and how they come about …

Abstract von Hippel‐Lindau (VHL) disease is a dominantly inherited familial cancer
syndrome resulting from mutations in the VHL tumor suppressor gene. VHL disease displays …

Hypoxia is defined as a decrease in available oxygen reaching the tissues of the body. It is
linked to the pathology of cancer, cardiovascular disease, and stroke, the leading causes of …

During endurance training, exercising skeletal muscle experiences severe and repetitive
oxygen stress. The primary transcriptional response factor for acclimation to hypoxic stress is …

Clear cell carcinoma of the kidney is a major cause of mortality in patients with von Hippel-
Lindau (VHL) disease, which is caused by germ line mutations that inactivate the VHL tumor …

During endurance training, exercising skeletal muscle experiences severe and repetitive
oxygen stress, and the muscle's ability to cope with and improve its function through that …

Background Somatic cytidine mutations in normal mammalian nuclear genes occur during
antibody diversification in B lymphocytes and generate an isoform of apolipoprotein B in …