Extensive human epidemiologic and animal model data indicate that during critical periods
of prenatal and postnatal mammalian development, nutrition and other environmental stimuli …

Many genes associated with CpG islands undergo de novo methylation in cancer. Studies
have suggested that the pattern of this modification may be partially determined by an …

OBJECTIVE: To review the current knowledge of the mechanism of DNA methylation, its
association with transcriptional silencing, possible mechanisms of hyper-and …

Maintenance of CG methylation (m CG) patterns is essential for chromatin-mediated
epigenetic regulation of transcription in plants and mammals. However, functional links …

Imprinted genes are essential in embryonic development, and imprinting dysregulation
contributes to human disease. We report two new human imprinted genes: KCNK9 is …

Human maintenance DNA cytosine methyltransferase (DNMT1) regulates gene expression
in a methylation-dependent and-independent manner. Anti-apoptotic survivin gene down …

It is generally assumed that transposable elements, including endogenous retroviruses
(ERVs), are silenced by DNA methylation/chromatin structure in mammalian cells. However …

DNA methylation of the X chromosome is reviewed and discussed, with emphasis on the
partial methylation seen in the mouse X‐linked Pgk1 promoter region. A new study of partial …

Redd1, a recently discovered stress-response gene, is regulated by hypoxia via hypoxia-
inducible factor 1 (HIF-1) and by DNA damage via p53/p63; however, the signaling pathway …

Background Tissue factor pathway inhibitor-2 (TFPI-2) is a matrix-associated Kunitz inhibitor
that inhibits plasmin and trypsin-mediated activation of zymogen matrix metalloproteinases …