Retinoic acid receptors (RARs) are ligand-controlled transcription factors that function as
heterodimers with retinoid X receptors (RXRs) to regulate cell growth and survival. The …

Gene targeting and overexpression studies have demonstrated the importance of the
clustered homeobox (HOX) genes in hematopoesis. In addition, global HOX gene …

PML and PU. 1 play important roles in myeloid differentiation. PML-deficient mice have an
impaired capacity for terminal maturation of their myeloid precursor cells. This finding has …

The aberrant function of transcription factors and/or kinase-based signaling pathways that
regulate the ability of hematopoietic cells to proliferate, differentiate, and escape apoptosis …

Apoptin, a protein of the chicken anemia virus (CAV), represents a novel potential anticancer
therapeutic, because it induces apoptotic death specifically in tumor but not normal cells …

Xeroderma pigmentosum group A (XPA)–binding protein 2 (XAB2) is composed of 855
amino acids, contains 15 tetratricopeptide repeat motifs, and associates with Cockayne …

Acute promyelocytic leukemia (APL) is an unique subtype of acute myeloid leukemia
typically carrying a specific reciprocal chromosome translocation, t (15; 17), leading to the …

In recent years, an impact of the p53 tumor suppressor protein in the processes of cellular
and organismal ageing became evident. First hints were found in model organisms like …

Over the past 10 years, work on acute promyelocytic leukemia (APL) has become the
paradigm of translational research that began with the discovery of a recurrent chromosomal …

The mechanisms underlying deregulation of HOX gene expression in AML are poorly
understood. The ParaHox gene CDX2 was shown to act as positive upstream regulator of …