Pathogenesis of chronic obstructive pulmonary disease

W MacNee - Clinics in chest medicine, 2007 - Elsevier
The pathogenesis of chronic obstructive pulmonary disease (COPD) encompasses a
number of injurious processes, including an abnormal inflammatory response in the lungs to …

Aspects on pathophysiological mechanisms in COPD

K Larsson - Journal of internal medicine, 2007 - Wiley Online Library
Chronic obstructive pulmonary disease (COPD) is a condition which is characterized by
irreversible airway obstruction due to narrowing of small airways, bronchiolitis, and …

Airway mucosal inflammation in COPD is similar in smokers and ex-smokers: a pooled analysis

E Gamble, DC Grootendorst… - European …, 2007 - Eur Respiratory Soc
Bronchial biopsy specimens from chronic obstructive pulmonary disease (COPD) patients
demonstrate increased numbers of CD8+ T-lymphocytes, macrophages and, in some …

IL-18 is induced and IL-18 receptor α plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation

MJ Kang, RJ Homer, A Gallo, CG Lee… - The Journal of …, 2007 - journals.aai.org
Th1 inflammation and remodeling characterized by local tissue destruction coexist in
pulmonary emphysema and other diseases. To test the hypothesis that IL-18 plays an …

Хроническая обструктивная болезнь легких и кардиоваскулярная патология

НА Кароли, АП Ребров - Клиницист, 2007 - cyberleninka.ru
Полиморбидность является одной из особенностей современной клиники внутренних
болезней, а ишемическая болезнь сердца (ИБС), артериальная гипертензия и …

Increased intracellular T helper 1 proinflammatory cytokine production in peripheral blood, bronchoalveolar lavage and intraepithelial T cells of COPD subjects

G Hodge, J Nairn, M Holmes… - Clinical & …, 2007 - academic.oup.com
The role of T cells in the pathophysiology of chronic obstructive pulmonary disease (COPD)
is not yet certain, although varying reports have shown increases in T helper 1 (Th1) and/or …

Effect of salmeterol/fluticasone propionate on airway inflammation in COPD: a randomised controlled trial

J Bourbeau, P Christodoulopoulos, F Maltais… - Thorax, 2007 - thorax.bmj.com
Background: Airway inflammation in chronic obstructive pulmonary disease (COPD) is
characterised by infiltration of CD8+ T cells and CD68+ macrophages and an increased …

Pulmonary inflammation and emphysema: role of the cytokines IL-18 and IL-13

T Hoshino, S Kato, N Oka, H Imaoka… - American journal of …, 2007 - atsjournals.org
Rationale: Chronic obstructive pulmonary disease (COPD) is believed to be an inflammatory
cytokine–driven disease, but a causal basis that can be associated with a specific cytokine …

Increased galectin-3 expression and intra-epithelial neutrophils in small airways in severe COPD

C Pilette, B Colinet, R Kiss, S André… - European …, 2007 - Eur Respiratory Soc
Galectins-1 and-3 regulate epithelial proliferation/apoptosis and neutrophil activation, and
are implicated in lung cancer and asthma. The role of galectins in chronic obstructive …

Exacerbations of asthma and chronic obstructive pulmonary disease (COPD): focus on virus induced exacerbations

P Mallia, M Contoli, G Caramori… - Current …, 2007 - ingentaconnect.com
Asthma and chronic obstructive pulmonary disease (COPD) are the 2 most prevalent chronic
airway diseases. Much of the morbidity, mortality and health care costs of the diseases are …