With a lifetime incidence of up to 12% in man and 6% in woman, nephrolithiasis is a major
health problem worldwide. Approximately, 80% of kidney stones are composed of calcium …

Chloride-transporting proteins play fundamental roles in many tissues in the plasma
membrane as well as in intracellular membranes. They have received increasing attention in …

A simple method is described to establish primary cultures of kidney proximal tubule cells
(PTC) on membranes. The permeable membranes represent a unique culture surface …

Urinary excretion of calcium is the result of a complex interplay between three organs—
namely, the gastrointestinal tract, bone, and kidney—which is finely orchestrated by multiple …

Megalin and cubilin are endocytic receptors highly expressed in the endocytic apparatus of
the renal proximal tubule. These receptors appear to be responsible for the tubular …

Renal stone disease (nephrolithiasis) affects 5% of adults and is often associated with
hypercalciuria. Hypercalciuric nephrolithiasis is a familial disorder in more than 35% of …

A series of novel, acyclic pyrrole-based anion receptors is described that bind nitrite and
carboxylate anions with good selectivity in dichloroethane solution. These systems, which …

Three distinct OCRL1 mutations in three patients with the Dent disease phenotype are
described. All the patients manifested an extremely high degree of low-molecular-weight …

Chloride channels are expressed along the entire mammalian nephron. They participate in
transepithelial chloride transport, cell volume regulation and acidification of intracellular …

Background The mammalian CLC protein family comprises nine members (ClC-1 to-7 and
ClC-Ka,-Kb) that function either as plasma membrane chloride channels or as intracellular …