Introduction High-frequency microsatellite instability (MSI-H) is an alternate pathway of
colorectal carcinogenesis, which accounts for 15% of all sporadic colorectal cancers. These …

Roughly 15% of colorectal tumors are characterized by microsatellite instability (MSI), a
deficiency caused by defective DNA mismatch repair, which leads to profuse insertions and …

Microsatellite instability (MSI) is observed in∼ 12% of colorectal cancers. Genes containing
a mononucleotide microsatellite in the coding sequence are particularly prone to inactivation …

We have comparatively analyzed mechanisms associated with chromosomal and
microsatellite instability in giant cell glioblastoma multiforme (gcGBM) and classic GBM. This …

AIM: Protein kinase Chk1 (hChk1) is essential in human cells for cell cycle arrest in
response to DNA damage, and has been shown to play an important role in the G2/M …

Patients with sporadic microsatellite instable colorectal cancers, in most of which the
function of the hMLH1 mismatch repair gene is impaired, do not gain a survival benefit from …

Laryngeal squamous cell carcinoma (LSCC) is a common cancer of the upper respiratory
tract. The cytogenetic and molecular events involved in the pathogenesis of LSCC are not …

Bei etwa 30% der Brustkrebspatienten ohne diagnostizierte Fernmetastasen (M0) können in
Knochenmark, Lymphknoten oder Blut Zellen mit epithelialen Eigenschaften gefunden …

Human telomeres are essential for maintaining chromosome stability and are composed of
TTAGGG repeat arrays with interspersed variant repeats at the proximal end. This work has …

Die IGFBP-2-Serumkonzentrationen sind beim menschlichen Kolonkarzinom mit dem
Tumorstadium signifikant positiv korreliert und sogar als prognostischer Marker für eine …