Acetaminophen is a commonly used antipyretic and analgesic agent. It is safe when taken at
therapeutic doses; however, overdose can lead to serious and even fatal hepatotoxicity. The …

Drug-induced liver injury depends initially on development of hepatocyte stress and cell
death, which can be induced directly by parent drugs or by toxic metabolites. Hepatocyte …

A large number of xenobiotics are reported to be potentially hepatotoxic. Free radicals
generated from the xenobiotic metabolism can induce lesions of the liver and react with the …

Featuring more than 4100 references, Drug-Induced Liver Disease is an invaluable
reference for gastroenterologists, hepatologists, family physicians, internists, pathologists …

Tu-Si-Zi, the seeds of Cuscuta chinensis Lam.(Convolvulaceae), is a traditional Chinese
medicine that is commonly used to nourish and improve the liver and kidney conditions in …

Abstract Acetaminophen (N‐acetyl‐p‐aminophenol [APAP]) is one of the leading causes of
acute liver failure, and APAP hepatotoxicity is associated with coagulopathy in humans. We …

Our previous microarray expression analysis of the long‐lived Little mice (Ghrhrlit/lit)
showed a concerted up‐regulation of xenobiotic detoxification genes. Here, we show that …

ABSTRACT Background: Acetaminophen (N‐acetyl-p‐aminophenyl; APAP) is the leading
drug used in self-poisoning and frequently causes hepatotoxicity, including acute liver …

Role of endoplasmic reticulum (ER) in liver injury by acetaminophen (AAP) was studied in
vivo in mice. Sublethal dose of AAP resulted in a decrease in microsomal total glutathione …

Drug-induced hepatitis remains a challenging problem for drug development and safety
because of the lack of animal models. In the current work, we discovered a unique …