Diabetes mellitus has been associated with an increased risk of several types of cancers,
but its relationship with breast cancer remains unclear. We conducted a meta‐analysis of …

Upper body obesity and the related metabolic disorder type 2 diabetes have been identified
as risk factors for breast cancer, and associated with late‐stage disease and a poor …

Background Mammographic density and circulating sex hormones are two well-confirmed
predictors of breast cancer risk. Whether mammographic density reflects levels of …

Background Although ecologic association and animal studies support a direct effect of
dietary fat on the development of breast cancer, results of epidemiologic studies have been …

The majority of candidates for breast cancer prevention have not accepted tamoxifen
because of the perception of an unfavorable risk/benefit ratio and the acceptance of …

Breast cancer, the second most common cause of cancer-related deaths in American
women, varies substantially in incidence and mortality according to race and ethnicity in the …

Purpose Phytoestrogens are plant compounds that are structurally and functionally similar to
mammalian estrogens. By competing for estrogen receptors, phytoestrogens possibly inhibit …

Multiple lines of evidence support a central role of hormones in the etiology of breast cancer.
In epidemiologic studies, considerable effort has focused on delineating the role of …

The CYP19A1 gene encodes the enzyme aromatase, which is responsible for the final step
in the biosynthesis of estrogens. In this study, we used a systematic two-step approach that …

Aromatase (CYP19) converts adrenal and ovarian androgens into estrogens, which
supports the growth of estrogen-dependent breast cancers. Anti-aromatase agents are …