This review is focused on purinergic neurotransmission, ie, ATP released from nerves as a
transmitter or cotransmitter to act as an extracellular signaling molecule on both pre-and …

Interstitial cystitis (IC) is a syndrome of bladder hypersensitivity with symptoms of urgency,
frequency, and chronic pelvic pain. Although no consensus has been reached on the …

The understanding of how pain is processed at each stage in the peripheral and central
nervous system is the precondition to develop new therapies for the selective treatment of …

Transient currents occur at rest in cortical neurones that reflect the quantal release of
transmitters such as glutamate and γ-aminobutyric acid (GABA). We found a bimodal …

This article presents an overview that gives some historical perspective to the detailed
papers at the cutting edge of P2 purinoceptor research that follow. I consider the proposal …

Bone marrow‐derived human mesenchymal stem cells (hMSCs) have the potential to
differentiate into several cell lines. Extracellular adenosine 5′‐triphosphate (ATP) acts as a …

Purine and pyrimidine nucleotides have been identified as potent extracellular signalling
molecules, acting at two classes of cell surface receptors, ionotropic P2X and metabotropic …

Our work aimed to provide a topographical analysis of all known ionotropic P2X 1–7 and
metabotropic P2Y 1, 2, 4, 6, 11–14 receptors that are present in vivo at the protein level in …

ATP is released during hypoxia from the ventrolateral medulla (VLM) and activates
purinergic P2 receptors (P2Rs) at unknown loci to offset the secondary hypoxic depression …

Presynaptic nerve terminals are equipped with a number of presynaptic auto-and
heteroreceptors, including ionotropic P2X and metabotropic P2Y receptors. P2 receptors …