During the past two decades significant advances have been made in the development of
biodegradable polymeric materials for biomedical applications. Degradable polymeric …

Gene therapy has long sought to treat disease by delivering therapeutic genes to diseased
cells. However, its widespread clinical use has faltered in the face of several challenges …

Chitosan nanoparticles fabricated via different preparation protocols have been in recent
years widely studied as carriers for therapeutic proteins and genes with varying degree of …

RNA interference (RNAi) is one of the most importantly protective phenomena forming from
the process combating against virus. Since its high efficiency for silencing the expression of …

We have previously introduced the use of the biomaterial chitosan to form chitosan/siRNA
nanoparticles for gene silencing protocols. This present study shows that the …

The study is focused on the evaluation of the potential bioadhesive behaviour of chitosan
and thiolated chitosan (chitosan-TBA)-coated poly (isobutyl cyanoacrylates)(PIBCA) …

The objective of this study is to construct complex of DNA and PLGA/HAp composite scaffold
for bone tissue engineering. Naked DNA has low transfection efficiency so DNA loaded …

Currently, the success of gene therapy is mainly limited due to the lack of effective vector
systems. Although viral vectors are highly efficient in transfecting cells, undesirable …

Films of chitosan and polyethylene glycol (PEG), with ciprofloxacin hydrochloride as model
drug incorporated at different concentrations, have been obtained by a casting/solvent …

In this work, nanoparticles with a negative or positive surface charge were prepared through
electrostatic interaction of an anionic cisplatin–alginate complex with a cationic …