Catharanthus terpenoid indole alkaloids: biosynthesis and regulation

M El-Sayed, R Verpoorte - Phytochemistry Reviews, 2007 - Springer
Catharanthus roseus is still the only source for the powerful antitumour drugs vinblastine
and vincristine. Some other pharmaceutical compounds from this plant, ajmalicine and …

Manipulating indole alkaloid production by Catharanthus roseus cell cultures in bioreactors: from biochemical processing to metabolic engineering

J Zhao, R Verpoorte - Phytochemistry Reviews, 2007 - Springer
Catharanthus roseus plants produce many pharmaceutically important indole alkaloids, of
which the bisindole alkaloids vinblastine and vincristine are antineoplastic medicines and …

Spatial distribution and hormonal regulation of gene products from methyl erythritol phosphate and monoterpene-secoiridoid pathways in Catharanthus roseus

A Oudin, S Mahroug, V Courdavault, N Hervouet… - Plant Molecular …, 2007 - Springer
The monoterpene indole alkaloids (MIAs) from Madagascar periwinkle (Catharanthus
roseus) are secondary metabolites of high interest due to their therapeutical values …

Analysis of Catharanthus roseus alkaloids by HPLC

S Hisiger, M Jolicoeur - Phytochemistry Reviews, 2007 - Springer
Catharanthus roseus is a medicinal plant from which secondary metabolites used in
chemotherapy to treat diverse cancers are extracted. The well known high value metabolites …

Expression of deacetylvindoline-4-O-acetyltransferase in Catharanthus roseus hairy roots

M Magnotta, J Murata, J Chen, V De Luca - Phytochemistry, 2007 - Elsevier
Madagascar periwinkle [Catharanthus roseus (L.) G Don] is a pantropical plant of
horticultural value that produces the powerful anticancer drugs vinblastine and vincristine …

Cellular and sub-cellular organisation of the monoterpenoid indole alkaloid pathway in Catharanthus roseus

S Mahroug, V Burlat, B St-Pierre - Phytochemistry Reviews, 2007 - Springer
Abstract The Madagascar periwinkle (Catharanthus roseus) monoterpene indole alkaloids
(MIAs), either as (hetero) dimers (vinblastine, vincristine) or as monomers (ajmalicine) are …

Accumulation and membrane transport of plant alkaloids

N Shitan, K Yazaki - Current pharmaceutical biotechnology, 2007 - ingentaconnect.com
Among a large number of plant secondary metabolites, alkaloids comprise one of the most
important groups due to their strong and divergent biological activities, and some are …

Opium poppy: blueprint for an alkaloid factory

PJ Facchini, JM Hagel, DK Liscombe… - Phytochemistry …, 2007 - Springer
Opium poppy (Papaver somniferum) produces a large number of benzylisoquinoline
alkaloids, including the narcotic analgesics morphine and codeine, and has emerged as …

Role of vacuolar transporter proteins in plant secondary metabolism: Catharanthus roseus cell culture

S Roytrakul, R Verpoorte - Phytochemistry Reviews, 2007 - Springer
Here the current status of knowledge on some well-characterized transporters located in the
vacuolar membrane is reviewed. As different cellular compartments and even different cells …

Catharanthus biosynthetic enzymes: the road ahead

VM Loyola-Vargas, RM Galaz-Ávalos… - Phytochemistry …, 2007 - Springer
Alkaloids are one of the most diverse groups of secondary metabolites found in living
organisms. The most economically important alkaloids are the bisindole vinblastine, and …