Abstract p53, p63 and p73 are members of the p53 gene family involved in development,
differentiation and response to cellular stress. p53 gene is a transcription factor essential for …

The p53 tumor suppressor‐signaling pathway is inactivated in most human cancers.
Depending on how p53 is targeted during tumorigenesis impacts whether partial or full …

Background p53 is commonly inactivated by mutations in the DNA-binding domain in a wide
range of cancers. As mutant p53 often influences response to therapy, effective and rapid …

Semaphorins are a large class of secreted or membrane-associated proteins that act as
chemotactic cues for cell movement via their transmembrane receptors, plexins. We …

Background Carcinomas of unknown primary site (CUP) are epithelial malignancies
revealed by metastatic lesions in the absence of any detectable primary tumor. Although …

The tumor suppressor gene TP53 is frequently inactivated by gene mutations in many types
of human sporadic cancers, and inherited TP53 mutations predispose to a wide spectrum of …

Results: The rapidity of diagnosis increased when bacteriological methods were combined
with PCR. Of 150 speciemens tested, 10 were positive for Neisseria meningitidis in PCR …

Purpose: Although p53 is one of the most studied genes/proteins in ovarian carcinomas, the
predictive value of p53 alterations is still ambiguous. Experimental Design: We performed …

Los objetivos de esta Tesis Doctoral fue estudiar el papel anti-apoptótico y de regulación
genética de la proteína p21 Cip1/Kip1. Los modelos celulares utilizados en este proyecto …

In this work, charge transport (CT) properties of the p53 gene are numerically studied by the
transfer matrix method, and using either single or double strand effective tight-binding …