DNA replication stress triggers the activation of Checkpoint Kinase 1 (Chk1) in a pathway
that requires the independent chromatin loading of the ATRIP–ATR (ATR-interacting …

Abstract Cdc13, Stn1 and Ten1 are essential yeast proteins that both protect chromosome
termini from unregulated resection and regulate telomere length. Cdc13, which localizes to …

Growing evidence suggests that the Rad9-Rad1-Hus1 complex (the 9-1-1 complex),
besides its functions in DNA damage sensing and signaling pathways, plays also a direct …

DNA replication is tightly controlled to ensure accurate chromosome duplication and
segregation in each cell cycle. Inactivation of Geminin, an inhibitor of origin licensing, leads …

Human (h) DNA repair enzyme thymine DNA glycosylase (hTDG) is a key DNA glycosylase
in the base excision repair (BER) pathway that repairs deaminated cytosines and 5-methyl …

Abstract The checkpoint protein Rad9/Rad1/Hus1 heterotrimer (the 9-1-1 complex) is
structurally similar to the proliferating cell nuclear antigen sliding clamp and has been …

The highly related acetyltransferases, p300 and CREB-binding protein (CBP) are
coactivators of signal-responsive transcriptional activation. In addition, recent evidence …

Abstract Subunits of the Rad9/Rad1/Hus1 (9-1-1) proliferating cell nuclear antigen (PNCA)-
like sliding clamp are required for DNA damage responses and telomerase-mediated …

The checkpoint proteins Rad9, Rad1 and Hus1 form a clamp-like complex which plays a
central role in the DNA-damage-induced checkpoint response. Here we address the …

Cell cycle checkpoints are evolutionarily conserved signaling pathways that uphold genomic
integrity. Complete inactivation of the mouse checkpoint gene Hus1 results in chromosomal …