Aberrant gene function and altered patterns of gene expression are key features of cancer.
Growing evidence shows that acquired epigenetic abnormalities participate with genetic …

An altered pattern of epigenetic modifications is central to many common human diseases,
including cancer. Many studies have explored the mosaic patterns of DNA methylation and …

Polycomb group (PcG) and trithorax group (trxG) proteins are critical regulators of numerous
developmental genes. To silence or activate gene expression, respectively, PcG and trxG …

Epigenetic gene inactivation in transformed cells involves many 'belts of silencing'. One of
the best-known lesions of the malignant cell is the transcriptional repression of tumor …

The Latin word" facultas" literally means" opportunity." Facultative heterochromatin (fHC)
then designates genomic regions in the nucleus of a eukaryotic cell that have the …

Methylation of cytosines can mediate epigenetic gene silencing and is the only known DNA
modification in eukaryotes. Recent efforts to map DNA methylation across mammalian …

The development of cancer is driven by the accumulation of scores of alterations affecting
the structure and function of the genome. Equally important in this process are genetic …

Pluripotent stem cells, similar to more restricted stem cells, are able to both self-renew and
generate differentiated progeny. Although this dual functionality has been much studied, the …

It has become increasingly evident in recent years that development is under epigenetic
control. Epigenetics is the study of heritable changes in gene function that occur …

De novo methylation of CpG islands is a common phenomenon in human cancer, but the
mechanisms of cancer-associated DNA methylation are not known. We have used tiling …