Emerging roles of cysteine cathepsins in disease and their potential as drug targets
O Vasiljeva, T Reinheckel, C Peters… - Current …, 2007 - ingentaconnect.com
The general view on cysteine cathepsins, which were long believed to be primarily involved
in intracellular protein turnover, has dramatically changed in last 10 to 15 years. The …
in intracellular protein turnover, has dramatically changed in last 10 to 15 years. The …
Neutrophil elastase up-regulates cathepsin B and matrix metalloprotease-2 expression
P Geraghty, MP Rogan, CM Greene… - The Journal of …, 2007 - journals.aai.org
Neutrophil elastase (NE) activity is increased in many diseases. Other families of proteases,
including cathepsins and matrix metalloproteases (MMPs), are also present at elevated …
including cathepsins and matrix metalloproteases (MMPs), are also present at elevated …
[HTML][HTML] Glycosaminoglycans facilitate procathepsin B activation through disruption of propeptide-mature enzyme interactions
Lysosomal cysteine cathepsin B participates in numerous diverse cellular processes. In
acquiring its activity, the proregion, which blocks the substrate-binding site in the …
acquiring its activity, the proregion, which blocks the substrate-binding site in the …
[HTML][HTML] Secretory leucocyte protease inhibitor inhibits interferon-γ-induced cathepsin S expression
We have demonstrated that bronchoalveolar lavage fluid from chronic obstructive pulmonary
disease patients contains higher levels of interferon-γ compared with controls. Interferon-γ is …
disease patients contains higher levels of interferon-γ compared with controls. Interferon-γ is …
Cysteine cathepsin non-inhibitory binding partners: modulating intracellular trafficking and function
BC Victor, BF Sloane - 2007 - degruyter.com
Cysteine cathepsins play a fundamental role in tumor growth, invasion and migration,
angiogenesis, and the metastatic cascade. Evidence of their overexpression in a wide array …
angiogenesis, and the metastatic cascade. Evidence of their overexpression in a wide array …
[引用][C] Neutrophil Elastase Up-Regulates Cathepsin
NG McElvaney, A Belaaouaj, SJ O'Neill, CC Taggart… - J Immunol, 2007