Salt formation is the most common and effective method of increasing solubility and
dissolution rates of acidic and basic drugs. In this article, physicochemical principles of salt …

Abstract Physicochemical and biopharmaceutical properties of drug substances and dosage
forms can be highly affected by the particle size, a critical process parameter in …

To improve the efficiency of orally delivered vaccines, PEGylated PLGA-based nanoparticles
displaying RGD molecules at their surface were designed to target human M cells. RGD …

The purpose of this study was to investigate the impact of different lipid based formulations
of lipophilic drugs on in vitro solubilization and intestinal ex vivo permeability processes …

The purposes of the review are to: a) Provide a comprehensible introduction of the-state-
ofthe-art sciences of solubility and dissolution, b) introduce typical technologies to assess …

An increasing number of newly developed drugs show bioavailability problems due to poor
water solubility. Formulating the drugs as nanosuspensions may help to overcome these …

Correlations between in vitro and in vivo data (IVIVC) are often used during pharmaceutical
development in order to reduce development time and optimize the formulation. A good …

On the basis of Pluronic® P104 as primary emulsifier and Lauroglycol® 90 as amphiphilic
oil phase, two nanoemulsion systems were developed with Pluronic® L62 or L81 as …

Kollicoat IR®, a new pharmaceutical excipient developed as a coating polymer for instant
release tablets, was evaluated as a carrier in solid dispersions of Itraconazole. The solid …

As the generic pharmaceutical industry continues to grow and thrive, so does the need to
conduct efficient and successful bioequivalence studies. In recent years, there have been …