Leptin and ghrelin are two hormones that have been recognized to have a major influence
on energy balance. Leptin is a mediator of long‐term regulation of energy balance …

Numerous circulating peptides and steroids produced in the body influence appetite through
their actions on the hypothalamus, the brain stem, and the autonomic nervous system …

Background A single family has been described in which obesity results from a mutation in
the leptin-receptor gene (LEPR), but the prevalence of such mutations in severe, early-onset …

Obesity is a risk factor for type 2 diabetes, dyslipidemia, and cardiovascular disease.
Dissection of the molecular mechanisms underlying obesity and its relationship to insulin …

Leptin is a hormone with pleiotropic functions affecting several tissues. Because leptin has a
crucial role in the adaptation of an organism to semi-starvation, anorexia nervosa (AN) …

A missense mutation in the ob gene causes leptin deficiency and morbid obesity. Leptin
replacement to three adults with this mutation normalized body weight and eating behavior …

Background and Purpose—Leptin is the major adipose hormone that regulates body weight
and energy expenditure by activating leptin receptors in the hypothalamus. Leptin receptors …

The brain has been recognized as a prominent site of peptide biosynthesis for more than 30
years, and many neuropeptides are now known to be common to gut and brain. With these …

In addition to playing a central role in energy homeostasis, leptin is also an important player
in the inflammatory response. Systemic inflammation is accompanied by fever (less severe …

More than 70 years ago the glucostatic, lipostatic and aminostatic hypotheses proposed that
the central nervous system sensed circulating levels of different metabolites, changing …