Abstract Ryanodine receptors (RyRs)/Ca2+ release channels, on the endoplasmic and
sarcoplasmic reticulum of most cell types, are required for intracellular Ca2+ release …

Superior fluorescence imaging methods are needed for detailed studies on biological
phenomena, and one approach that permits precise analyses is time-resolved fluorescence …

Although the exact nature of the relationship between calcium and the pathogenesis of
Duchenne muscular dystrophy (DMD) is not fully understood, this is an important issue …

Cell signalling requires efficient Ca2+ mobilization from intracellular stores through Ca2+
release channels, as well as predicted counter-movement of ions across the sarcoplasmic …

Stimuli are translated to intracellular calcium signals via opening of inositol trisphosphate
receptor and ryanodine receptor (RyR) channels of the sarcoplasmic reticulum or …

Since the discovery of the Ca2+ spark as an elementary event of cellular Ca2+ signaling
almost 15 years ago, the family of newly described Ca2+ signal entities has been ever …

Duchenne muscular dystrophy is caused by mutations in the dystrophin gene and is
characterized by progressive muscle wasting. The highly conserved dystrophin gene …

Ryanodine receptors (RyRs) function as intracellular Ca2+ release channels on the
endoplasmic and sarcoplasmic reticulum membranes. In striated muscles, Ca2+ release …

Ca+ sparks are rare in healthy adult mammalian skeletal muscle but may appear when adult
fiber integrity is compromised, and occur in embryonic muscle but decline as the animal …

Spontaneous Ca 2+ release occurs in cardiac cells during sarcoplasmic reticulum Ca 2+
overload, a process we refer to as store-overload-induced Ca 2+ release (SOICR). Unlike …