Manipulation of the cellular stress response offers strategies to protect brain cells from
damage induced by ischemia and neurodegenerative diseases. Overexpression of Hsp70 …

The occurrence of endoplasmic reticulum (ER) stress in the sporadic form of amyotrophic
lateral sclerosis (ALS) is unknown, despite it has been recently documented in experimental …

The ability to mount a successful stress response in the face of injury is critical to the long‐
term viability of individual cells and to the organism in general. The stress response …

Abstract Misfolding of Cu/Zn-superoxide dismutase (SOD1) is emerging as a mechanism
underlying motor neuron degeneration in individuals with amyotrophic lateral sclerosis …

Amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative disorder that results
in the progressive loss of motoneurons (MNs) in the CNS. Several survival and death …

Roy Walford, a physician and scientist who pioneered research on the anti-aging effects of
caloric restriction and subjected himself to a low-energy diet, recently died from amyotrophic …

Spinal and bulbar muscular atrophy (SBMA) or Kennedy's disease is a motor neurone
disease characterized by muscle atrophy, weakness, contraction fasciculations and bulbar …

One familial form of the neurodegenerative disease, amyotrophic lateral sclerosis, is caused
by gain-of-function mutations in the gene encoding copper/zinc superoxide dismutase (SOD …

Neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis have been termed protein misfolding disorders that are …

Hsp70 is a multi‐gene family composed of stress‐inducible members (Hsp70) and other
members that are constitutively expressed (Hsc70). The heat shock proteins Hsp70 and …