Postreplicative maintenance of genomic methylation patterns was proposed to depend
largely on the binding of DNA methyltransferase 1 (Dnmt1) to PCNA, a core component of …

The spatial organization of replicons into clusters is believed to be of critical importance for
genome duplication in higher eukaryotes, but its functional organization still remains to be …

The origin recognition complex (ORC) was initially discovered in budding yeast extracts as a
protein complex that binds with high affinity to autonomously replicating sequences in an …

Cyclin A/Cdk2 plays an important role during S and G2/M phases of the eukaryotic cell cycle,
but the mechanisms by which it regulates cell cycle events are not fully understood. We have …

Abstract Rat Myo16a and Myo16b comprise the founding members of class XVI myosin and
are characterized by an N‐terminal ankyrin repeat domain thought to mediate an …

In response to DNA damage, cells activate a complex protein network designed to sustain
genomic integrity. Many of the proteins involved in the network form discrete repair foci, the …

Background DNA replication in higher eukaryotic cells is organized in discrete subnuclear
sites called replication foci (RF). During the S phase, most replication proteins assemble at …

An optical switch exhibits two stable and selectively addressable states, a fluorescent state
and a non-fluorescent state, which can be reversibly interconverted upon irradiation with …

The regeneration of adult skeletal muscle is mediated by a small population of cells known
as satellite cells. While a great deal is known about the events that occur following satellite …

The results obtained from the experiments presented in this study aimed to further explore
the role of cyclin dependent kinases and cyclins in the protozoan parasite Leishmania …