Background—Embryonic stem (ES) cells are distinguished by their capacity for self-renewal
and pluripotency. Here we characterize the differentiation of ES cell–derived endothelial …

Ferritin, the iron storage protein, was recently suggested to be a candidate reporter for the
detection of gene expression by magnetic resonance imaging (MRI). Here we report the …

The mechanisms that are responsible for the restricted pattern of expression of the VE-
cadherin gene in endothelial cells are not clearly understood. Regulation of expression is …

Blood vessels form a highly organized hierarchical network throughout the vertebrate body,
integrate functionally into very different tissue environments and remain remarkably …

To identify an endothelial cell-specific promoter suitable for vascular-specific targeting, we
tested five promoters in vitro--Tie2SE, Tie2LE, ICAM2, Flt-1 and vWF--for promoter activity …

This chapter reviews the exciting progress in design and application of novel candidate
reporter genes that may allow detection of the transcriptional regulation of gene expression …

Murine, embryonale Stammzellen dienen als Modell der frühen Embryonalentwicklung der
Maus. Indem der Einfluss von Wachstumsfaktoren auf die Differenzierung untersucht wird …

Cardiovascular disease is one of the leading causes of death in the Western world. One of
the most common causes is the rupture of unstable atherosclerotic plaques, which can lead …

Danio rerio, commonly referred to as zebrafish, represent a powerful genetic and
developmental model organism for the study of cardiovascular development. The genetic …

Obesity is an epidemic with rising prevalence worldwide. Obesity poses a major risk for
chronic diseases including hypertension, type II diabetes and cardiovascular disease. The …