Suppression of NF-κB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes …
M Shakibaei, T John, G Schulze-Tanzil… - Biochemical …, 2007 - Elsevier
Pro-inflammatory cytokines such as interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-
α) play a key role in the pathogenesis of osteoarthritis (OA). Anti-inflammatory agents …
α) play a key role in the pathogenesis of osteoarthritis (OA). Anti-inflammatory agents …
Differential regulation of cytokine release and leukocyte migration by lipopolysaccharide-stimulated primary human lung alveolar type II epithelial cells and …
Bacterial colonization is a secondary feature of many lung disorders associated with
elevated cytokine levels and increased leukocyte recruitment. We hypothesized that …
elevated cytokine levels and increased leukocyte recruitment. We hypothesized that …
[图书][B] Biomolecular action of ionizing radiation
S Lehnert - 2007 - taylorfrancis.com
Embracing the transformation of radiation sciences by the recent surge of developments in
molecular biology, this progressive text offers an up-to-date analysis of in vitro and in vivo …
molecular biology, this progressive text offers an up-to-date analysis of in vitro and in vivo …
Baicalein induces cancer cell death and proliferation retardation by the inhibition of CDC2 kinase and survivin associated with opposite role of p38 mitogen-activated …
JI Chao, WC Su, HF Liu - Molecular cancer therapeutics, 2007 - AACR
The bioactive flavonoid baicalein has been shown to have in vitro growth-inhibitory activity
in human cancer cells, although the mechanism of action is poorly understood. Baicalein (40 …
in human cancer cells, although the mechanism of action is poorly understood. Baicalein (40 …
Regulation of type II collagen expression by histone deacetylase in articular chondrocytes
YH Huh, JH Ryu, JS Chun - Journal of Biological Chemistry, 2007 - ASBMB
Histone deacetylase (HDAC) regulates various cellular processes by modulating gene
expression. Here, we investigated the role of HDAC in the expression of type II collagen, a …
expression. Here, we investigated the role of HDAC in the expression of type II collagen, a …
Body composition and knee cartilage properties in healthy, community-based adults
Background: Although obesity is widely accepted as a risk factor for knee osteoarthritis,
whether weight per se or the specific components of body composition are the major …
whether weight per se or the specific components of body composition are the major …
Apoptosis induced by NO via phosphorylation of p38 MAPK that stimulates NF‐κB, p53 and caspase‐3 activation in rabbit articular chondrocytes
H Wang, Z Wang, J Chen, J Wu - Cell biology international, 2007 - Wiley Online Library
Nitric oxide (NO), reported as an important inducer of apoptosis, plays a considerable role in
the pathogenetic mechanisms of articular diseases. This research aimed at investigating the …
the pathogenetic mechanisms of articular diseases. This research aimed at investigating the …
Phosphatidylinositol 3-kinase, MEK-1 and p38 mediate leptin/interferon-gamma synergistic NOS type II induction in chondrocytes
In a previous study, we established that leptin acts synergistically with interferon-γ in
inducing nitric oxide synthase type II in cultured chondrocytes via Janus kinase-2 activation …
inducing nitric oxide synthase type II in cultured chondrocytes via Janus kinase-2 activation …
Activation of p38 mitogen-activated protein kinase by celecoxib oppositely regulates survivin and gamma-H2AX in human colorectal cancer cells
PW Hsiao, CC Chang, HF Liu, CM Tsai, TH Chiu… - Toxicology and applied …, 2007 - Elsevier
Cancer cells express survivin that facilitates tumorigenesis. Celecoxib has been shown to
reduce human colorectal cancers. However, the role and regulation of survivin by celecoxib …
reduce human colorectal cancers. However, the role and regulation of survivin by celecoxib …
PARP-1-induced cell death through inhibition of the MEK/ERK pathway in MNNG-treated HeLa cells
C Ethier, Y Labelle, GG Poirier - Apoptosis, 2007 - Springer
Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) hyper-activation promotes cell death but
the signaling events downstream of PARP-1 activation are not fully identified. To gain further …
the signaling events downstream of PARP-1 activation are not fully identified. To gain further …