AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
DG Hardie - Nature reviews Molecular cell biology, 2007 - nature.com
The SNF1/AMP-activated protein kinase (AMPK) family maintains the balance between ATP
production and consumption in all eukaryotic cells. The kinases are heterotrimers that …
production and consumption in all eukaryotic cells. The kinases are heterotrimers that …
AMP-activated protein kinase in metabolic control and insulin signaling
MC Towler, DG Hardie - Circulation research, 2007 - Am Heart Assoc
The AMP-activated protein kinase (AMPK) system acts as a sensor of cellular energy status
that is conserved in all eukaryotic cells. It is activated by increases in the cellular AMP: ATP …
that is conserved in all eukaryotic cells. It is activated by increases in the cellular AMP: ATP …
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
S Jäger, C Handschin, J St.-Pierre… - Proceedings of the …, 2007 - National Acad Sciences
Activation of AMP-activated kinase (AMPK) in skeletal muscle increases glucose uptake,
fatty acid oxidation, and mitochondrial biogenesis by increasing gene expression in these …
fatty acid oxidation, and mitochondrial biogenesis by increasing gene expression in these …
Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis
RM Reznick, H Zong, J Li, K Morino, IK Moore… - Cell metabolism, 2007 - cell.com
Recent studies have demonstrated a strong relationship between aging-associated
reductions in mitochondrial function, dysregulated intracellular lipid metabolism, and insulin …
reductions in mitochondrial function, dysregulated intracellular lipid metabolism, and insulin …
Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase
O Göransson, A McBride, SA Hawley, FA Ross… - Journal of Biological …, 2007 - ASBMB
We have studied the mechanism of A-769662, a new activator of AMP-activated protein
kinase (AMPK). Unlike other pharmacological activators, it directly activates native rat AMPK …
kinase (AMPK). Unlike other pharmacological activators, it directly activates native rat AMPK …
AMP-activated protein kinase as a drug target
DG Hardie - Annu. Rev. Pharmacol. Toxicol., 2007 - annualreviews.org
The AMP-activated protein kinase (AMPK) system is a regulator of energy balance at both
the cellular and whole-body levels that, once activated by low energy status, effects a switch …
the cellular and whole-body levels that, once activated by low energy status, effects a switch …
AMPK activation stimulates myofibrillar protein degradation and expression of atrophy-related ubiquitin ligases by increasing FOXO transcription factors in C2C12 …
K Nakashima, Y Yakabe - Bioscience, biotechnology, and …, 2007 - Taylor & Francis
In skeletal muscle, AMP-activated protein kinase (AMPK) is a metabolic master switch
regulating glucose and lipid metabolism. Recently, AMPK has been implicated in the control …
regulating glucose and lipid metabolism. Recently, AMPK has been implicated in the control …
Regulation of snf1 protein kinase in response to environmental stress
SP Hong, M Carlson - Journal of Biological Chemistry, 2007 - ASBMB
The Saccharomyces cerevisiae Snf1 protein kinase, a member of the Snf1/AMPK (AMP-
activated protein kinase) family, has important roles in metabolic control, particularly in …
activated protein kinase) family, has important roles in metabolic control, particularly in …
Adiponectin and AMP kinase activator stimulate proliferation, differentiation, and mineralization of osteoblastic MC3T3-E1 cells
I Kanazawa, T Yamaguchi, S Yano, M Yamauchi… - BMC cell biology, 2007 - Springer
Background Adiponectin is a key mediator of the metabolic syndrome that is caused by
visceral fat accumulation. Adiponectin and its receptors are known to be expressed in …
visceral fat accumulation. Adiponectin and its receptors are known to be expressed in …
Effects of metformin on bovine granulosa cells steroidogenesis: possible involvement of adenosine 5′ monophosphate-activated protein kinase (AMPK)
L Tosca, C Chabrolle, S Uzbekova… - Biology of …, 2007 - academic.oup.com
In mammals, IGFs are important for the proliferation and steroidogenesis of ovarian cells.
Metformin is an insulin sensitizer molecule used for the treatment of the infertility of women …
Metformin is an insulin sensitizer molecule used for the treatment of the infertility of women …