The metalloproteinases degrade extracellular matrix (ECM) components and activate growth
factors, thereby contributing to physiological events (tissue remodeling in pregnancy, wound …

Background and Purpose—The degradation of extracellular matrix (ECM) is a hallmark of a
cerebral aneurysm; however, little is known regarding the molecular mechanism leading to …

The growth hormone 1/insulin-like growth factor-1 (GH1/IGF-1) axis plays an essential role
in the development of the breast by regulating cell proliferation, differentiation and …

Purpose: Matrix metalloproteinases (MMP) promote tumor invasion and alter
microenvironment. MMP levels are elevated in bladder cancer patients correlating with more …

Abstract Background Cutaneous Malignant Melanoma causes over 75% of skin cancer-
related deaths, and it is clear that many factors may contribute to the outcome. Matrix …

Poor embryo implantation can lead to poor feto-maternal exchanges and intrauterine growth
restriction. Matrix metalloproteinase-2 (MMP-2) and MMP-9 are highly involved in early …

BACKGROUND AND PURPOSE: The molecular characteristics of intracranial aneurysms
are still poorly documented. A rabbit elastase aneurysm model has been helpful in the …

Background: An underlying extracellular matrix defect is suspected in patients with
spontaneous cervical artery dissection (SCAD). We test the hypothesis that levels of matrix …

Background. There is evidence suggesting that genetic variants in the chondroitin sulfate
proteoglycan2 (CSPG2, also known as versican) gene are involved in the pathogenesis of …

Matrix metalloproteinase-9 (MMP-9) plays roles in cancer progression by degrading the
extracellular matrix and basement membrane. Many growth factors including Transforming …