Contrary to the view that embryos and larvae are the most fragile stages of life, development
is stable under real-world conditions. Early cleavage embryos are prepared for …

Risk assessment of metal-contaminated habitats based on responses in the field is
complicated by the evolution of local, metal-resistant ecotypes. The unpredictability of …

A comprehensive understanding of the cellular functions of the Hsp90 molecular chaperone
has remained elusive. Although Hsp90 is essential, highly abundant under normal …

The molecular chaperone HEAT SHOCK PROTEIN90 (HSP90) is essential for the
maturation of key regulatory proteins in eukaryotes and for the response to temperature …

Background Probabilistic functional gene networks are powerful theoretical frameworks for
integrating heterogeneous functional genomics and proteomics data into objective models …

Robust biological signaling networks evolved, through gene duplications, from simple,
relatively fragile cascades. Architectural features such as layered configuration, branching …

Compromised heat shock protein 90 (Hsp90) function reveals cryptic phenotypes in flies and
plants. These observations were interpreted to suggest that this molecular stress-response …

The molecular chaperone HSP90 aids the maturation of a diverse but select set of
metastable protein clients, many of which are key to a variety of signal transduction …

Protein homeostasis maintains proper intracellular balance by promoting protein folding and
clearance mechanisms while minimizing the stress caused by the accumulation of misfolded …

The molecular chaperone, Hsp90, facilitates the maturation and/or activation of over 100
'client proteins' involved in signal transduction and transcriptional regulation. Largely an …