G protein-coupled receptors (GPCRs) are widely implicated in human heart disease, making
them an important target for cardiac drug therapy. The most commonly studied and clinically …

The cardiac sarcoplasmic reticulum calcium ATPase (SERCA2a) plays a critical role in
maintaining the intracellular calcium homeostasis during cardiac contraction and relaxation …

Dilated cardiomyopathy and hypertrophic cardiomyopathy (HCM) can be caused by
mutations in thin filament regulatory proteins of the contractile apparatus. In vitro functional …

The National Heart, Lung, and Blood Institute and Office of Rare Diseases at the National
Institutes of Health organized a workshop (September 14 to 15, 2006, in Bethesda, Md) to …

The β‐adrenergic receptor/cyclic AMP/protein kinase A (PKA) signalling pathway regulates
heart rate and contractility. Here, we identified a supramolecular complex consisting of the …

Junctophilin-2 (JPH2) is a cardiac specific member of the junctophilins, a newly
characterized family of junctional membrane complex proteins important in physically …

Point mutations in cardiac myosin, the heart's molecular motor, produce distinct clinical
phenotypes: hypertrophic (HCM) and dilated (DCM) cardiomyopathy. Do mutations alter …

It has been six years since the first reported link between mutations in the cardiac ryanodine
receptor Ca2+ release channel (RyR2) and catecholaminergic polymorphic ventricular …

Dilated cardiomyopathy (DCM) is a myocardial disease characterized by dilatation and
impaired systolic function of the left or both ventricles. The etiology of DCM is multifactorial …

Objectives: The purpose of this study was to develop a clinically applicable high-efficiency
percutaneous means of therapeutic gene delivery to the failing heart. Background …