In the vertebrate embryo, multiple cell types originate from a common structure, the neural
crest (NC), which forms at the dorsal tips of the neural epithelium. The NC gives rise to …

Vertebrate neural crest development depends on pluripotent, migratory precursor cells.
Although avian and murine neural crest stem (NCS) cells have been identified, the isolation …

Neural crest stem cells were first isolated from early embryonic neural crest in the early
1990s, but in the past 5 years, there has been a burst of discoveries of neural crest‐derived …

Aims: Enteric nervous system (ENS) progenitor cells have been postulated to be an
appropriate source of cells for the treatment of Hirschsprung's disease. In order for this to be …

After peripheral nerve injury, the number of sensory neurons in the adult dorsal root ganglia
(DRG) is initially reduced but recovers to a normal level several months later. The …

We have systematically examined the developmental potential of neural crest stem cells
from the enteric nervous system (gut NCSCs) in vivo to evaluate their potential use in …

The enteric nervous system arises from vagal (caudal hindbrain) and sacral level neural
crest-derived cells that migrate into and along the developing gut. Data from previous …

An intact enteric nervous system is required for normal gastrointestinal tract function. Several
human conditions result from decreased innervation by enteric neurons; however, the …

The neural crest (NC) is a highly motile cell population that gives rise to multiple tissue
lineages during vertebrate embryogenesis. Here, we identify a novel effector of the small …

One might think that Hirschsprung's disease (congenital megacolon) should be passé as a
medical problem. After all, many genes, including RET, GDNF, NRTN, EDNRB, EDN3 …