Cytokines regulate a broad range of inflammatory processes that are implicated in the
pathogenesis of rheumatoid arthritis. In rheumatoid joints, it is well known that an imbalance …

Osteoimmunology is an interdisciplinary research field focused on the molecular
understanding of the interplay between the immune and skeletal systems. Although …

For over 35 years, immunologists have divided T-helper (TH) cells into functional subsets. T-
helper type 1 (TH1) cells—long thought to mediate tissue damage—might be involved in the …

T cell–mediated autoimmune diseases such as multiple sclerosis and rheumatoid arthritis
are driven by autoaggressive Th cells. The pathogenicity of such Th cells has, in the past …

Upon activation, naïve CD4+ T cells differentiate into effector T cells with specific effector
functions and cytokine profiles. The Th1/Th2 paradigm has recently been reevaluated to …

Abstract Objective To investigate whether Treg cells can suppress osteoclast differentiation,
and to define a new potential link between the immune system and the skeleton. Methods …

Rheumatoid arthritis (RA) is one of the most common chronic inflammatory syndromes. As
such, RA is often considered the prototype disease for defining both the molecular and …

IL-17 and its receptor are founding members of a novel family of inflammatory cytokines. IL-
17 plays a pathogenic role in rheumatoid arthritis (RA)–associated bone destruction …

Abstract Objective Interleukin‐17 (IL‐17)–producing T helper cells have been proposed to
represent a separate lineage of CD4+ cells, designated Th17 cells, which are regulated by …

Abstract Interleukin (IL)‐17 is a proinflammatory cytokine which induces differentiation and
migration of neutrophils through induction of cytokines and chemokines including …