The phosphoinositide 3-kinase (PI3K) pathway is frequently activated in human cancer and
represents an attractive target for therapies based on small molecule inhibitors. PI3K …

DNA copy number amplifications activate oncogenes and are found in the majority of
advanced solid tumors. Cell-lineage specificity and oncogene affinity of DNA amplifications …

Context: Genetic alterations in the phosphatidylinositol-3-kinase (PI3K)/Akt pathway and
their role in thyroid tumor pathogenesis in Chinese people remain undefined. Objective: The …

To explore the significance of phosphatidylinositol‐3‐kinase, catalytic, alpha (PIK3CA) in the
carcinogenesis in human lung, mutations and copy number changes were investigated in …

Alterations in genomic content and changes in gene expression levels are central
characteristics of tumors and pivotal to the tumorigenic process. We analyzed 23 non-small …

Mitogen-activated protein kinase kinase-4 (MKK4/SEK1) cooperates with
phosphatidylinositol 3-kinase to maintain the survival of non-small cell lung cancer (NSCLC) …

We have investigated 92 non-small cell lung cancer tissues and found 11 PIK3CA
amplification. PIK3CA amplification incidence was significantly higher in male, smoker and …

Genomic alterations have been identified in lung cancer tissues and reported in numerous
studies. To analyze genomic aberrations in lung cancer patients, we used array comparative …

Background Lung cancer is the leading cause of cancer-related death worldwide. Currently,
tumor, node, metastasis (TNM) staging provides the most accurate prognostic parameter for …

The phosphoinositide 3-kinase signaling network is widely implicated in the pathogenesis of
human cancer. This pathway is commandeered by cancer cells to promote unrestrained …