Abstract Programmed cell death-1 (PD-1, Pdcd1), an immunoreceptor belonging to the
CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein …

The programmed cell death 1 (PD-1) surface receptor binds to two ligands, PD-L1 and PD-
L2. Studies have shown that PD-1–PD-L interactions control the induction and maintenance …

The past year has seen significant advances in our understanding of the critical roles of
negative immunoregulatory signals delivered by the programmed death 1 (PD-1)–PD-1 …

Recent findings have substantiated the importance of T lymphocytes to the pathogenesis of
rheumatoid arthritis (RA). Here, we review emerging data regarding genetic predisposition …

Context: A recent large-scale analysis of nonsynonymous coding polymorphisms showed
strong evidence that an alanine to threonine amino acid change at codon 946 of the …

Interaction between Programmed cell death-1 (PD-1), a member of costimulatory molecules,
and its receptors Programmed cell Death-1 Ligand 1 (PD-L1) and Programmed cell Death-1 …

Acquisition of a complex immune system during evolution provided organisms with the most
effective defense mechanism against “foreign&rdquo or “non-self&rdquo invaders. This …

Dendritic cells (DCs) are central cells of the immune responses. They can be considered as
the most influential antigen-presenting cells in the body because of their unique role in …

Background As genes associated with immune-mediated diseases have an increased prior
probability of being associated with other immune-mediated diseases, we tested three such …

Objective To determine the potential role of the CD24 A57V gene polymorphism in systemic
lupus erythematosus (SLE). Methods We studied 3 cohorts of Caucasian patients and …