Intermediate filaments (IFs) constitute a major structural element of animal cells. They build
two distinct systems, one in the nucleus and one in the cytoplasm. In both cases, their major …

Intermediate filaments (IFs) play a key role in the integration of structure and function of
striated muscle, primarily by mediating mechanochemical links between the contractile …

Interactions of mitochondria with the cytoskeleton are crucial for normal mitochondrial
function and for localization of the organelle at its sites of action within cells. Early studies …

Over the past decade there has been considerable progress in elucidating the signaling
pathways involved in cardioprotection. Considerable recent data suggest that many of these …

Publisher Summary This chapter focuses on the methods to visualize mitochondria and
quantify their dynamic properties in living mammalian cells. The methods described to …

Intermediate filaments, composed of desmin and of keratins, play important roles in linking
contractile elements to each other and to the sarcolemma in striated muscle. We examined …

Myofibrillar myopathy (MFM) encompasses a genetically heterogeneous group of human
diseases caused by mutations in genes coding for structural proteins of muscle. Mutations in …

New roles have emerged recently for intermediate filaments (IFs), namely in modulating cell
adhesion and growth, and providing resistance to various forms of stress and to apoptosis …

Desmin, the muscle-specific intermediate filament protein, surrounds the Z disks and links
the entire contractile apparatus to the sarcolemmal cytoskeleton, cytoplasmic organelles …

Mitochondrial abnormalities represent a major cytopathology in Huntington's disease (HD),
a fatal neurodegenerative disease caused by CAG repeat expansions in the gene encoding …