Iodine is a trace element that is essential for the synthesis of thyroid hormone. Both chronic
iodine deficiency and iodine excess have been associated with hypertrophy and …

A novel hypothesis of thyroid carcinogenesis, the “fetal cell carcinogenesis” hypothesis, in
which cancer cells are derived from the remnants of three types of fetal thyroid cells, instead …

Frequency of a BRAF V600E mutation in anaplastic thyroid carcinoma, which is thought to
be derived mainly from papillary carcinoma by multi-step carcinogenesis, is much lower than …

Papillary thyroid carcinoma (PTC) represents an example of tumour with high incidence of
oncogenic sequences, such as RET/PTC and Trk. Both of them arise from the fusion of …

Insulin like-growth factor I (IGF-I) has been involved in the pathogenesis of a variety of
human neoplasia due to the mitogenic and anti-apoptotic properties of its cognate receptor …

The large use of simple and effective diagnostic tools has significantly contributed to the
increase in diagnosis of thyroid cancer over the past years. However, there is compelling …

Aufgabe der Schilddrüse ist die Synthese und Freisetzung von Schilddrüsenhormonen.
Schilddrüsenhormone beeinflussen zahlreiche Stoffwechselprozesse. Sowohl die …

Objective: Thyroid cancer is the most common endocrine malignancy. Molecular
mechanisms underlying this disorder are heterogeneous and need to be clarified. Different …

Background There have been some investigations concerning the role of p53, p21 and bcl-2
protein expressions for the tumorigenesis of thyroid cancer. It had been debated that these …

The process of carcinogenesis is permanently one of the most interesting and significant
issues for researchers in different fields of medicine. Therefore, we attempted to bring closer …