Signaling pathways that activate different mitogen-activated protein kinases (MAPKs) elicit
many of the responses that are evoked in cells by changes in certain environmental …

PH (pleckstrin homology) domains represent the 11th most common domain in the human
proteome. They are best known for their ability to bind phosphoinositides with high affinity …

The establishment of cell polarity is critical for the development of many organisms and for
the function of many cell types. A large number of studies of diverse organisms from yeast to …

The exocyst is an octameric protein complex implicated in the tethering of post‐Golgi
secretory vesicles to the plasma membrane before fusion. The function of individual exocyst …

It is now well appreciated that derivatives of phosphatidylinositol (PtdIns) are key regulators
of many cellular processes in eukaryotes. Of particular interest are phosphoinositides (mono …

Summary Calcineurin, the conserved Ca 2+/calmodulin-regulated protein phosphatase,
mediates diverse aspects of Ca 2+-dependent signaling. We show that substrates bind …

The TOR kinases are regulators of growth in eukaryotic cells that assemble into two distinct
protein complexes, TORC1 and TORC2, where TORC1 is inhibited by the antibiotic …

Abstract Phosphatidylinositol (4, 5)-bisphosphate (PIP 2) is an important lipid mediator that
has multiple regulatory functions. There is now increasing evidence that the …

The PH domain-containing proteins Slm1 and Slm2 were previously identified as effectors of
the phosphatidylinositol-4, 5-bisphosphate (PI4, 5P 2) and TORC2 signaling pathways …

Complex sphingolipids in yeast are known to function in cellular adaptation to environmental
changes. One of the yeast complex sphingolipids, mannosylinositol phosphorylceramide …