Our understanding of the different glycoconjugates present on cells, proteins and entire
organisms is lagging far behind advances in genomics and proteomics. Carbohydrate …

Carbohydrate chemistry constitutes today a “multifaceted” discipline strongly connected with
organic, pharmaceutical, and medicinal chemistry. 1 Carbohydrates are important …

Carbohydrates are involved in a wide range of biological processes,,,. These structurally
diverse compounds are more complex than other biological polymers, and are often present …

The diversity of three major classes of mammalian carbohydrates, mainly glycolipids and O-
and N-linked glycans, deposited in the databank GLYCOSCIENCES. de was subjected to …

Saccharide synthesis is a formidable task for synthetic chemists. Although in recent years
many advances have been made in this area, development of more convenient and efficient …

A highly enantioselective and straightforward route to trisaccharide natural products
digoxose and digitoxin has been developed. Key to this approach is the iterative application …

Dimethyl disulfide reacts with triflic anhydride to provide a highly reactive electrophile.
Various thioglycosides, differing in their thio aglycons, carbohydrate units, and protecting …

Sugar-assisted ligation (SAL) presents an attractive strategy for the synthesis of
glycopeptides, including the synthesis of cysteine-free β-O-linked and N-linked …

Protein glycosylation is an important post-translational modification of proteins that has
profound effects on structure and function. However, the complex and non-templated nature …

Glycosynthases are mutant glycosidases in which the acidic nucleophile is replaced by a
small inert residue. In the presence of glycosyl fluorides of the opposite anomeric …