Background Over the last several years, it has become apparent that there are critical
problems with the hypothesis that brain dopamine (DA) systems, particularly in the nucleus …

This review summarizes recent developments that have contributed to understand how
adenosine receptors, particularly A2A receptors, modulate brain injury in various animal …

The mechanism of action responsible for the motor depressant effects of cannabinoids,
which operate through centrally expressed cannabinoid CB 1 receptors, is still a matter of …

Future therapies in Parkinson's disease may substantially build on the existence of intra‐
membrane receptor–receptor interactions in DA receptor containing heteromeric receptor …

Rationale Organisms frequently make effort-related decisions based upon assessments of
motivational value and response costs. Energy-related dysfunctions such as psychomotor …

The aim of this review is to summarize and critically discuss the complex role played by
adenosine A2A receptors (A2ARs) in Huntington's disease (HD). Since A2ARs are mainly …

Adenosine and dopamine (DA) strongly modulate the neuronal activity in the striatum by pre-
and postsynaptic mechanisms. As several behavioral and molecular studies indicate a …

Heptaspanning membrane also known as G protein-coupled receptors (GPCR) do interact
with a variety of intracellular proteins whose function is regulate receptor traffic and/or …

There is considerable evidence of interactions between adenosine A2A receptors and
dopamine D2 receptors in striatal areas, and antagonists of the A2A receptor have been …

Adenosine is one of the principal neuromodulators in the brain and acts on four specific
receptor subtypes: the A1, A2A, A2B and A3 receptors. Adenosine concentrations normally …