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Many of the remaining challenges in infectious disease control involve pathogens that fail to
elicit long-lasting immunity in their hosts. Antigenic variation is a common reason for this …

During the past decade, sequencing of the entire genome of pathogenic bacteria has
become a widely used practice in microbiology research. More recently, sequence data from …

In this review we aim to provide the reader with an understanding of the capsular-based
complexity of Streptococcus pneumoniae, one of the main limitations to current vaccine …

The usefulness of rapid pathogen genotyping is widely recognized, but its effective
interpretation and application requires integration into clinical and public health decision …

Identification of antigens that elicit protective immunity is essential for effective vaccine
development. We investigated the related surface proteins of group B Streptococcus, Rib …

Background. Two promising recombinant meningococcal protein vaccines are in
development. One contains factor H-binding protein (fHBP) variants (v.) 1 and 2, whereas …

The best way to prevent diseases caused by pathogens is by the use of vaccines. The
advent of genomics enables genome-wide searches of new vaccine candidates, called …

The current explosion in new high-throughput technologies arising from microbial and
animal genomics studies is enabling the analysis of the genome, transcriptome, and …

The use of vaccines in the prevention of meningococcal disease has demonstrated their
success in improving public health globally. Group C conjugate vaccines have significantly …